New research reveals that patients who come off blockbuster slimming jabs like Wegovy and Mounjaro can put back on lost weight far faster than those who halt traditional diet and exercise regimens.
Research printed in a prominent health publication demonstrates that while obese people can lose about a fifth of their total mass while undergoing treatment, the mass returns at an average rate of 0.8 kg per month after stopping.
"Individuals buying such medications need to be cognizant of the potential of fast rebound weight gain when the therapy is stopped," stated researcher Dr. Susan Jebb.
That rate of recovery means a reversion to starting mass in about 18 months.
Analyzing Treatments
The analysis, which looked at 37 of trials involving over 9,000 of patients, contrasted the outcomes of these new drugs with conventional dieting.
Researchers note that individuals who lose weight through lifestyle changes alone typically experience a slower weight regain—approximately 100 grams monthly—post-intervention.
Explaining the Rapid Rebound
Doctors propose the mechanism of the drugs accounts for the accelerated rebound.
These medications copy a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Sustained high doses of the hormone concentrations far above than the body's typical production could lead to the system to generate a reduced amount of its endogenous GLP-1, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this hormone supplement leads to hunger is unsuppressed, making binge eating much more probable."
A Chronic Issue?
Medical guidelines advise the jabs for people with obesity-related health risks, alongside recommended lifestyle changes.
Many experts say that, due to the high risk of weight regain, the treatment might need to be long-term.
This opinion is supported by pharmaceutical companies, who state that the results "underscore the persistent nature of obesity," akin to managing diseases like hypertension.
Patient Accounts
Users who have discontinued the jabs describe a sudden return of cravings.
"It felt as if something activating and you become starving," described a patient.
This difficulty is exacerbated if users have not established sustainable dietary or behavioural modifications during treatment.
Growing Use
Recent estimates show that a significant number of adults in the UK have used these injections in the past year, with demand continuing to grow.
- Use is greater among women compared to males.
- The middle-aged age group shows the greatest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while these medications are potent agents for shedding pounds, they are not a permanent fix and long-term success hinges on combined lifestyle management.
